What is FMT?
Fecal Microbiota Transplantation (FMT) is an innovative investigational treatment that has – in randomized, controlled clinical trials – resolved 80-90% of infections caused by recurrent C. difficile that does not respond to antibiotics. During FMT, a fecal preparation from a carefully screened, healthy stool donor is instilled into the colon of the patient. There are multiple routes of administration (e.g., via colonoscopy or capsules), each of which has unique risks and benefits. In the US, this therapy is not FDA approved for any indication but under a policy from the FDA we can offer this for patients with C. difficile infection not responding to standard therapy. Despite the challenges of the COVID-19 pandemic, the Allegretti Lab has continued to offer this therapy to patients in need.
F.A.Q.
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Dr. Allegretti offers FMT treatment through colonoscopy and capsule administrations at this time. Material is obtain from a stool bank, so patients do not need to provide their own donor.
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Patients who experienced 3 or more confirmed episodes of C. difficile infection within 12 months are eligible for FMT treatment at our site. The clinic will ask to review your C. difficile test results prior to scheduling your appointment.
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Dr. Allegretti will review your medical history and test results with you and will review available therapy options for C. difficile infection.
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We work with a stool bank that performs all the donor screening and prepares the material for treatment.
If you are interested in a consultation please call 617-732-6389. Be prepared to send over your recent C. difficile test results which will be required prior to scheduling.